In PC, Kirsten ras sarcoma, signal transducer and activator of transcription 3, insulin-like growth factor-2 mRNA-binding protein, and high mobility group AT-hook 2(HMGA/HMGA2) are among the validated targets of let-7 .16 Because most of the current studies with miRNAs are in vitro, more studies are needed to determine their role in patients before they become predictive biomarkers and therapeutic targets in cancer treatment. This evidence concerns the gene HMGA2 and pachyonychia congenita.