HMGA2 and colorectal cancer: The increase in let-7 expression causes the expression of HMGA2 protein to be suppressed.25,26 Another study conducted in colorectal cancer cell lines showed that decreased HMGA2 protein expression causes sensitivity to 5-FU.27 In our study, the OS and PFS were significantly higher in FOLFIRINOX patients with high let-7c and 7d levels, suggesting that HMGA2 protein was suppressed.