Second, in patients with modestly elevated Lp(a) levels above 50 mg/dl but below 180 mg/dl at intermediate or high risk, Lp(a) can also lead to a significant risk increase [hazard ratio for myocardial infarction: 2.0, 95% CI (1.5–2.7)] [14]. The gene discussed is LPA; the disease is myocardial infarction.