A study in 17 families with oculodentodigital dysplasia identified genetic variants in GJA1 (the gene encoding Cx43) and several cardiac abnormalities, including ventricular arrhythmias.8 Using GWAS, Bezzina and co-workers9 also suggested that genetic variants around genes regulating connexin cellular localization might be a risk factor of MI. Here, GJA1 is linked to myocardial infarction.