Previous bioinformatic analysis has shown that Cx43 has a role in MI.9 Both the H248R and the V236I variants have been potentially associated with oculodentodigital dysplasia (H248R, variant of unknown significance) and hypoplastic left heart syndrome 1, syndactyly type 3, oculodentodigital dysplasia (V236I). The gene discussed is GJA1; the disease is hypoplastic left heart syndrome.