PDPN and lung adenocarcinoma: LUAD seems to be more often associated with hypoxic regions, such as hypoxic regions of lung adenocarcinoma presenting a CAFs tumor microenvironment with abundant tumor promoting stromal cells, CD204 (+) TAMs, and podoplanin (+) CAFs, which contributes to an increase in aggressive behavior in lung adenocarcinoma with hypoxic regions [17].