Salivary levels of miR-1246 in patients with chronic periodontitis were positively correlated with the levels of IL-1β, IL-6, IL-17, TNF-α, MMP-1, MMP-8, and TIMP-1 (P < 0.05), as shown in figures 1, , , , , –7. This evidence concerns the gene MMP1 and chronic periodontitis.