The network pharmacology results revealed that differentially expressed genes, involving in EGFR tyrosine kinase inhibitor resistance, endocrine resistance, HIF-1 signaling pathway, C-type lectin receptor signaling pathway, FOXO signaling pathway, hepatitis B, influenza virus infection, PI3K-Akt signaling pathway, and pathways in cancer, contributed to the IAV-induced alveolar macrophage dysfunction. This evidence concerns the gene AKT1 and hepatitis B virus infection.