In this study, HJRG can effectively inhibit collagen accumulation and HYP contents in liver tissues; reduce serum PC III, Col IV, LN, and HA levels, and the overexpression of α-SMA, desmin, and vimentin in the liver tissue; inhibit the activation of HSC and ECM deposition in the liver, thereby inhibiting liver fibrosis. The gene discussed is DES; the disease is Hepatic fibrosis.