DES and Hepatic fibrosis: Moreover, the increase of inflammatory cytokines leads to further aggravation in the oxidative stress, thereby maintaining a vicious circle, leading to the conversion of HSCs from a resting state to myofibroblast-like cells, then activating the myofibroblasts, which are responsible for matrix remodeling and the increasing levels of ECM proteins such as collagen, desmin, vimentin, and laminin [9], thereby leading to liver fibrosis, liver cirrhosis, and liver cancer.