TNF-α, IL-1β, and IL-6 mainly contribute to HSCs activation; Cox2 and iNOS are the main regulators of the inflammatory response; Cox2 induces prostaglandin E2 (PGE2) production and then mediates inflammation in the liver disease models [47]; the continuous production of NO is associated with the increased iNOS expression. The gene discussed is IL1B; the disease is liver disorder.