Our study found that HJRG significantly inhibited the increase of p-IκBα, p-P65/P65, p-ERK/ERK, p-JNK/JNK, and MAPK p-P38/P38 ratios in the liver tissue of rats with hepatic fibrosis and the protein expression levels of TNFR1. This evidence concerns the gene TNFRSF1A and Hepatic fibrosis.