INS and type 2 diabetes mellitus: The main finding of the present analysis is that aiming for more ambitious (lower) fasting plasma glucose titration targets leads to slightly but significantly better glycemic control as measured by the resulting fasting plasma glucose and HbA1c concentrations after titrating basal insulin in insulin-naïve patients with type 2 diabetes on a background of oral glucose-lowering medications (Table 3, Figure 1).