ANTXR1 and colorectal cancer: Anthrax toxin receptor 1 (ANTXR1), a type I transmembrane protein, also known as tumor endothelial marker 8 (TEM8), was initially identified because of its overexpression in the endothelial cells (ECs) that is associated with human colorectal cancer [9–12] Previous studies had not shown an association between ANTXR1 and hematological phenotypes until the recent finding that a single nucleotide polymorphism (SNP, rs4527238, T>C) in intron 9 of the ANTXR1 gene was associated with the regulation of HbF levels in Saudi patients with SCD [13].