For example, increased level of Cx3cl1 was reported after HFD consumption and induced neuroinflammation-relevant process (Morari et al., 2014; Gonzalez-Portilla et al., 2021), while decreased Cx3cl1 expression in hippocampus and amygdala was reported in HFD-induced obese mice that showed significant cognitive deficits (Kawamura et al., 2021). Here, CX3CL1 is linked to Cognitive impairment.