To our knowledge, the brain levels of many proteins have not been reported to be associated with HFD, obesity or hyperlipidemia, including Mettl3, Rbfox1, Dab1, Srgap1, Kcnq5, Sbno1, Gpr56, Nrp2, Fam96b, Slc6a5, Lrfn2, Pde8a, Gan, Fat3, Cmtr1, Cntnap5a, Iqgap1, Flrt2, Lzic, Syt6, Kirrel3, Snap29, Scamp5, Akt1s1, Cfap20, Lims1, Pik3r2, CI072, Arid1b, Rab27b, Lrfn1, Grasp, Jph4, Tmem35, Emb, Mycbp2, Efnb1, Gfra1, Aatk, Actl6b, Lrrtm4, Epha7, Olfm2, Cplx1 and Gprc5b (full names in Table 1). Here, SYT6 is linked to obesity due to melanocortin 4 receptor deficiency.