Moreover, as far as we know, the brain levels of Ces1c, Anxa2, Spin1, Gstm2, Smyd3, Fam73b, Selenof, Lbr, Mia2, Mvk, Fabp3, Atg2a, Sdcbp, Hmgcs2, Mlst8, Col4a2, Smpd2, Ugt8, Degs1 and Cers6 have not been reported to be correlated with HFD, obesity or hyperlipidemia (full names in Table 1). Here, SMYD3 is linked to obesity due to melanocortin 4 receptor deficiency.