TGFB1 and open-angle glaucoma: When compared to POAG, eyes with PXG had a more substantial impairment of the blood-aqueous barrier after trabeculectomy [7–9], and an increased concentration of transforming growth factor-β (TGF-β) in aqueous humor [10, 11], which is known to regulate transdifferentiation of fibroblasts into myofibroblasts for wound healing and scar formation [12, 13].