In contrast, SOX11 (p < 0.001, FDR < 0.001) and MYC (p = 0.02, FDR = 0.06) were the top two up-regulated genes in noninflamed tumors relative to inflamed tumors, suggesting SOX11 and MYC might contribute to poor immunoreactivity in SCLC (Fig. 2C and Supplementary Fig. 3A). This evidence concerns the gene MYC and small cell lung carcinoma.