All the possible targets of the COVID‐19 diagnosis are membrane protein, glycoprotein, and viral genomic RNA which insist on instant immune response upon binding with host angiotensin‐converting enzyme‐2 (ACE‐2) receptors, while the humoral response is refered by immunoglobulin M (IgM) and immunoglobulin G (IgG) Abs. Here, CD40LG is linked to COVID-19.