WNK2 and osteosarcoma: In addition, subsequent studies have shown that NF-κB signaling and the mitogen-activated protein kinase (MAPK) pathway have a certain connection with ferroptosis, and downregulating the MAPK pathway by the ferroptosis inhibitor Fer-1 could promote osteosarcoma cell death, thus recovering from osteosarcoma and reducing ROS production (Figure 4(d)) [17, 108–110].