HDAC2 and cancer: In addition to MCM2 to MCM7, six downstream oncogenic targets of c-MYC implicated in cancer survival and metabolism including PSMA1, PSMA6, PSMB2, HDAC2, LDHA and SPRING [42–45] were positively correlated with IFITM3 in 71 GC specimens using the Cho dataset [27] (Fig. 7B, and Additional file 1: Fig. S1C).