The only report that showed the ability of IFITM3 in regulating c-MYC expression was via ERK1/2 signaling to promote tumorigenesis in HCC [21], in which IFITM3 was also reported to enhance the invasiveness and metastasis of HCC through regulation of p38/MAPK/MMP9 signaling [17]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.