Consistently, the gene expressions of MCM2, MEM3, MCM4, PSMA1, PSMA6, PSMB2, LDHA and SPRING were significantly elevated in IFITM3-overexpressing TMK-1 cells, while reduced expressions were observed in IFITM3-silenced TSGH cells (Fig. 7C and Additional file 1: Fig. S1D), further supporting IFITM3 as a positive regulator in MET/AKT/c-MYC signal axis in GC. This evidence concerns the gene VPS35 and gastric cancer.