For the offspring from the mHF group, although the blood glucose levels in an OGTT and AUC between the HF group (born by natural delivery) and HF-CS groups (born by C-section) were not comparable, the lower serum insulin level in the HF-CS group than the HF group showed an altered insulin resistance of the offspring derived from the mHF group was mitigated by C-section (Fig. 2b–d). This evidence concerns the gene INS and hydrops fetalis.