Finally, based on the KEGG analysis of Yi-qi-hua-yu-jie-du decoction in gastric cancer treatment and combined with the using of IGF-1 and si-Nrf2, we found that YQHY prevented the activation of the PI3K/Akt/Nrf2 pathway thus to restrain the drug resistance of BGC823/5–Fu-CSCs. This evidence concerns the gene AKT1 and gastric cancer.