Among the ISGs, cytokines like tumor necrosis factor ligand superfamily member 13B (TNFSF13B; also known as B cell-activating factor, BAFF), and chemokines such as CCL5, CXCL10, and CXCL12, could be continuously secret by FLSs in the inflamed RA synovium. This evidence concerns the gene TNFSF13B and rheumatoid arthritis.