To our surprise, three probes of BCAM, including cg06522456 (p < 0.01), cg08319238 (p < 0.001) and cg14037553 (p < 0.01), showed higher level of methylation in ccRCC with BAP1 mutation compared to BAP1 wild-type ccRCC, indicating the potential mechanism of BAP1 mutation regulating BCAM expression level (Additional file 3: Fig. S1H). Here, BCAM is linked to nonpapillary renal cell carcinoma.