BCAM and nonpapillary renal cell carcinoma: In our present study, we found that in ccRCC, some DNA methylation status, including hypermethylation of cg14037553, cg17489534, cg24122751, cg22640961, cg12249345, cg21978694 and cg23318764, could explain the downregulation of BCAM. Although DNA mutation and CNV burden did not affect the dysregulation of BCAM, the genetic analysis found BCAM low expression had a closer association with higher TMB and high frequency of BAP1 mutation.