As the results illustrated, BCAM gene positively correlated with the expression of most methylation related enzymes in ccRCC, such as MECP2 (r = 0.399, p < 0.001), MBD3 (r = 0.28, p < 0.001) and TET2 (r = 0.244, p < 0.001). The gene discussed is BCAM; the disease is nonpapillary renal cell carcinoma.