CD4 and nonpapillary renal cell carcinoma: After mining data from TCGA cohort, we found that in ccRCC samples, most immune cell types were increased in BCAM-low subgroup, such as M2 macrophage (p < 0.001), monocyte (p < 0.001), myeloid dendritic cell (p < 0.001), CD8 + T cells (p < 0.001) and CD4 + Th2 cells (p < 0.001) (Fig. 5A).