For example, statins exert anticancer effects by inhibiting the activity of the key rate-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the cholesterol synthesis signaling pathway [5], and itraconazole directly binds to the sterol-sensitive domain of NPC intracellular cholesterol transporter 1 (NPC1), thereby reducing tumor growth and angiogenesis [6]. Here, HMGCR is linked to neoplasm.