In order to explore the relationship between the cholesterol metabolism pathway proteins affected by the identified SOAT1-targeting compounds and the survival of liver cancer patients, we retrospectively compared and analyzed the proteome data of clinical liver cancer patients in the Chinese Human Proteome Project (CNHPP) (http://liver.cnhpp.ncpsb.org/), transcriptome data of TCGA (https://www.genome.gov/Funded-Programs-Projects/Cancer-Genome-Atlas) liver cancer patients, and our proteome data generated in this study. Here, SOAT1 is linked to liver cancer.