Modules from various immune cells, including CD4+ T cells, CD8+ T cells, B cells, NK cells, monocytes, dendritic cells (DCs), and neutrophils, showed significant correlation with either the diagnosis of BS or clinical features of BS patients, suggesting the contribution of various immune cells to the pathogenesis of BS (Fig. 1), and some of those modules were further examined. This evidence concerns the gene CD8A and Bloom syndrome.