BCHE and posterior cortical atrophy: As shown in Fig. 3A, the cholinesterase activity in the PCa cell culture supernatant decreased significantly after GW4869 treatment (GW4869-10uM/20uM vs. 2B4-NC, p = 0.0010/p = 0.0022; GW4869-10uM/20uM vs. 1E8-NC, p < 0.0001/p < 0.0001) which indirectly confirmed that GW4869 inhibited the secretion of PCa cell exosomes, and there was no observed difference between the 10 and 20 μM treatments.