MRC1 and posterior cortical atrophy: The results from Fig. 3C demonstrate that 10 μM GW4869 significantly decreased the number of CD206+ macrophages (2B4-GW4869 vs. 2B4-exo-Mφ, p = 0.0182; 1E8-GW4869 vs. 1E8-exo-Mφ, p = 0.0003), suggesting that GW4869 could inhibit macrophage differentiation into M2 cells through blocking the secretion of exosomes from PCa cells.