The finding that SHP-1 agonists and ruxolitinib suppressed p-STAT3, whereas only SHP-1 agonists effectively suppressed p-Lyn and induced PARP cleavage suggesting SHP-1/p-Lyn axis might play a more important role in mediating the apoptosis effects in DLBCL cells, and supported the role of BCR signaling in DLBCL. Here, LYN is linked to diffuse large B-cell lymphoma.