LYN and diffuse large B-cell lymphoma: For example, a raft-associated signalosome made of the constitutively active Lyn kinase, the tyrosine phosphorylated Cbp/PAG adaptor, and tyrosine phosphorylated STAT3 transcription factor (the Lyn-Cbp/PAG signalosome), appears to control proliferation and survival in several B-NHLs cells including DLBCL cell lines SU-DHL-6, OCI-Ly3, and constitutes a therapeutic target in B-NHL cells that exhibit oncogenic “addiction” to the Lyn kinase (Tauzin et al. 2008).