We then subset and clustered the epithelial lineage cells and identified the normal acinar (Amy1+ and Amy2a2+) and islet/ductal cells (Pyy+ and Sst+, Ins1+ and Ins2+) as well as a cancer cell cluster with normal epithelial lineage marker expression excluded (Sox9+ and Krt18+) (Fig. 1A–C). Here, PYY is linked to cancer.