One recent histological investigation revealed a significant down-regulation of four specific EIF subunits, namely EIF1, EIF2D, EIF3C and EIF6, suggesting not only EIF2 signaling, but also other members of the EIF family were of relevance in pancreatic tumor biology and might play a major role in translational control in PDAC82. The gene discussed is EIF2S1; the disease is pancreatic neoplasm.