Recently, it has further been shown that expression of B7-H3 and subsequent immune evasion in HNSCC is regulated by a long non-coding RNA (LINC01123) through repression of miRNA(miR-214-3p)-mediated inhibition of B7-H3 expression (Li et al. 2022) and that especially HNSCC cancer stem cells (CSCs) utilize B7-H3 to evade immune surveillance. Here, CD276 is linked to head and neck squamous cell carcinoma.