CD276 and laryngeal neoplasm: Regarding the interplay of B7-H3 expression and patient treatment, significantly favorable survival upon strong staining was observed after primary (chemo)radiation (RT/RCT) in the whole HPV- cohort (p = 0.023) (Fig. 3 E), which was largely based on profound differences in laryngeal tumors and p16- OPSCC (Supplementary Fig. 3B).