Whether, and if so to what extent, immune modulatory or immune-independent functions of B7-H3 may contribute to a given enhanced radio(chemo)sensitivity of HPV- HNSCC with strong B7-H3 expression and whether this needs to be considered for potential combination therapy with anti-B7-H3 antibodies is an important question for future research. This evidence concerns the gene CD276 and head and neck squamous cell carcinoma.