Many of these TFs play important roles in tumor biology including TEAD1 via regulation of YAP/Hippo signaling20–23, TCF4 via regulation of Wnt/β-catenin signaling24, ZEB1 via regulation of epithelial to mesenchymal transition25,26, and AR via mediation of radiation resistance in GBM27,28. This evidence concerns the gene TCF4 and neoplasm.