TF and neoplasm: Using the ArchR package and chromVAR method18,19, we identified 141 TFs with differential binding activity across the primary tumor cells (Fig. 1g), 103 of which had motif deviation scores18 that correlated with inferred gene expression, i.e., gene scores (Fig. 1h), which provided greater confidence in the putative role of a particular TF in modulating expression behavior of downstream target genes.