ADAR1 showed a positive correlation with CD8 (ρ = 0.50, p < 0.001), PD-1 (ρ = 0.51, p < 0.001), and PD-L1 (ρ = 0.61, p < 0.001; Fig. 1D), providing evidence that the upregulation of ADAR1 may be associated with the immunological response to CRC. This evidence concerns the gene CD8A and colorectal carcinoma.