Recent in silico studies identified EGR3 as a central gene in a network of transcription factors and microRNAs associated with schizophrenia risk [2], a master regulator of genes that are differentially regulated in bipolar disorder patients [3], and a critical regulator of DEGs involved in synaptic function in Alzheimer’s disease [4]. Here, EGR3 is linked to early-onset autosomal dominant Alzheimer disease.