Emphasizing the importance of BRD1-regulated transcription in normal brain development and function, BRD1 has, in the general population, been associated with the surface area of the cerebral cortex as measured by magnetic resonance imaging [29, 30], and haploinsufficient Brd1+/− mice are characterized by changes in neurochemistry, brain-, and synapse morphometry accompanied by behavioral alterations and cognitive impairments with broad translational relevance to psychiatric disorders [14, 31–33]. This evidence concerns the gene BRD1 and Cognitive impairment.