CHAC1 and metabolic dysfunction-associated steatohepatitis: As expected from NASH-induced ER stress and the concomitant increase in p-eif2α and total eif2α expression (Figure 5A,B), other genes whose expression is increased by ER-stress and p-eIf2α activity (Sesn2, Chac1, Atf3, Ddit3 and Trib3) were increased by GAN diet feeding (Figure 5C).