Accordingly, while GAN diet-induced NASH increased p-eIf2α and total eif2α expression (Figure 5A,B), GAN diet-induced NASH by itself did not activate Oma1 nor Opa1 processing (Figure 5A) and was also unable to upregulate Asns expression (Figure 5C). This evidence concerns the gene OPA1 and metabolic dysfunction-associated steatohepatitis.