EIF2A and metabolic dysfunction-associated steatohepatitis: Accordingly, while GAN diet-induced NASH increased p-eIf2α and total eif2α expression (Figure 5A,B), GAN diet-induced NASH by itself did not activate Oma1 nor Opa1 processing (Figure 5A) and was also unable to upregulate Asns expression (Figure 5C).