Seven out of the eleven reported positive associations were replicated in our Japanese cohort with P < 0.05, including those at LZTFL1, FOXP4, TMEM65, ABO, TAC4, DPP9 and IFNAR2 (Fig. 1a and Supplementary Table 3), where the highest odds ratios were observed in comparisons for severe and young (less than 65 years of age) COVID-19 cases in 6 out of the 7 loci. The gene discussed is LZTFL1; the disease is COVID-19.