The A allele of the lead SNP (rs60200309), located at an intergenic region downstream of DOCK2, was associated with an increased risk of severe COVID-19 (odds ratio = 2.01, 95% confidence interval 1.58–2.55, P = 1.2 × 10−8; Fig. 1c and Table 1). This evidence concerns the gene DOCK2 and COVID-19.