IFNG and neoplasm: In coculture of CAR T cells with IL13Rα1-expressing tumor cells (A549 and HT1080-IL13Rα1) at a 1:1 E:T ratio, WT and E12Y induced significantly more surface expression of CD107a (Fig. 5A) and intracellular expression of IFN-γ (Fig. 5B) than C4 and D7 (P < 0.05 for all comparisons).