RIGI and viral infectious disease: Surprisingly, MDA5 and RIG-I deficiencies (RIG-I and MDA5 double-KO) did not promote DENV replication in any of the conditions, indicating that the upregulation of the dsRNA sensors is unlikely to be the main contributing factor to the diminished viral infection in TMEM41B KO and VMP1 KO cells (Fig 2E and 2F).