Approximately two-thirds of WT mice (12/18) displayed signs of severe encephalitis (score > 3) with a mean disease score of 3 at 14 dpi, and one-sixth of Anx-A1-/- mice (2/12) displayed severe encephalitis with a mean disease score of 0.7, which was significantly lower than that of WT mice (Fig 5A). The gene discussed is ANXA1; the disease is viral encephalitis.