Previous evidence has confirmed the vital roles of chemokines in the progression of BC, such as the overexpression of chemokines in mammary fibroblasts regulated by MEKK1, which can form a TME that supports the migration of BC cells [50], as well as the promotion of migration of ING4-deficient BC cells induced by CXCL10 chemokines [51]. This evidence concerns the gene ING4 and breast cancer.