The PCa exposure cohort included 5714 men (median [IQR] age, 72 [11.0]) diagnosed with PCa and 28 445 men (median [IQR] age, 72 [11.0]) without PCa, whereas the GnRH agonist–exposure cohort included 692 men with PCa and receiving GnRH agonists and 3460 men with PCa but not receiving GnRH agonists. Here, GNRH1 is linked to posterior cortical atrophy.