GNRH1 and type 2 diabetes mellitus: Several studies have previously reported on the association of use of GnRH agonists with CVD risk and mortality, although not in men with type 2 diabetes in particular.7,28,29 Based on these studies, the American Heart Association, along with the American Cancer Society and the American Urological Association, published a joint statement highlighting an association between use of GnRH agonists and increased risk of CVD.30