GNRH1 and type 2 diabetes mellitus: GnRH agonist use may be associated with elevated blood pressure because of its reduction in testosterone.39 However, several observational studies reported no change in blood pressure after 12 months of treatment with GnRH agonists.11,12,40 Testosterone has been shown to activate both vasodilator and vasoconstrictor pathways, which may explain the inconsistent results.38,41 In our study, use of GnRH agonists and PCa diagnosis were associated with lower blood pressure in men with type 2 diabetes.