In 2020, a meta-analysis4 reported an association between GnRH agonist use and acute myocardial infarction, with a risk ratio of 1.73 (95% CI, 1.05-2.85), as well as coronary heart disease, with a risk ratio of 2.09 (95% CI, 1.02-4.30). This evidence concerns the gene GNRH1 and coronary artery disorder.