GNRH1 and posterior cortical atrophy: We observed an association between use of GnRH agonists and increased predicted 5-year CVD risk score in men with PCa receiving GnRH agonists compared with men with PCa not receiving GnRH agonists (10% increase in the score: HR, 1.53; 95% CI, 1.35-1.74) (Table 2; eTable 2 in the Supplement).