Collective evidence supports a role for PDGF in HL pathogenesis,35 and PDGFD is a transforming, angiogenic growth factor.10 In addition, 12 of 18 previously reported genome-wide significant non-HLA SNVs (67%) were replicated with P < .05 (eTable 4 in the Supplement). Here, PDGFD is linked to Hodgkins lymphoma.