ABCG2 and hyperuricemia: Here we analysed the relation between the four most common clinically relevant functional single nucleotide polymorphisms (SNP) of ABCG2 gene in the studied population and the main clinical hyperuricemia parameters along with susceptibility and the characteristics of severe gout such as early onset of the disease, the number of occurring flares (flare/past 12 months) and the presence or absence of subcutaneous tophi [23, 24].