The two common variants p.T138N and p.S186N in SFTPC gene were reported in two different studies, one in adult German (IPF) patients with age ranging from 24 to 61 years and the other in familial pulmonary fibrosis cases within population of Reunion Island, represented with unexplained respiratory distress (URD) [27, 28]. This evidence concerns the gene SFTPC and idiopathic pulmonary fibrosis.