Consistent with the idea that dysregulated activation of STIM1/Orai1-dependent SOCE promotes Ca2+-mediated muscle fiber degeneration in muscular dystrophy, STIM1 and Orai1 expression levels and SOCE activity were reported to be increased in dystrophin-deficient mdx mice (Edwards et al., 2010; Zhao et al., 2012; Cully et al., 2012). This evidence concerns the gene STIM1 and muscular dystrophy.