Gene ontology (GO) analysis of genes affected by AP usage shows enrichment in critical CLL pathways, for example, NF-κB signaling (Pekarsky et al., 2008), MAPK signaling (Shukla et al., 2018), Toll-like receptor signaling (Spaner and Masellis, 2007), phosphatidylinositol 3-kinase signaling (Barragán et al., 2002), chromatin regulation/acetylation, and other relevant GOs (Supplementary file 1). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.