DNMT3A and B-cell chronic lymphocytic leukemia: A previous study described decreased methylation levels in Eμ-Tcl1 mice and in CLL patients and reported a strong interaction between TCL1 and de novo DNA methyl transferases DNMT3A and 3B along with inhibition of the enzymatic activity (Palamarchuk et al., 2012), suggesting for direct inhibition of de novo methylation during leukemogenesis.