A heterogeneous pattern of cytokines involving CD4+ and CD8+ T cells has been described in ADRs with the development of maculopapular exanthema (19, 29), and two cases of overlapping clinical manifestations of drug reaction with eosinophilia and systemic symptoms and Stevens-Johnson syndrome/toxic epidermal necrolysis have been reported in subjects infected with T. cruzi treated with benznidazole (30). Here, CD8A is linked to toxic epidermal necrolysis.