Additionally, we also found that the increased SBP, DKD, decreased serum Alb, Scr, higher CKD stages, presence of proteinuria, prevalence of CVD were independent risk factors for the KRT endpoint; the increased age, decreased Hb level, decreased serum Alb level were independent risk factors for all-cause death endpoint; the increased age, decreased serum Alb level were independent risk factors for CVD events endpoint. The gene discussed is GSTM1; the disease is chronic kidney disease.