The Cox regression model with KRT endpoint as an outcome showed that the increased SBP (HR: 1.012, 95% CI [1.003–1.020], p < 0.05), DKD (HR for DKD vs. NDKD: 1.604, 95%CI [1.049–2.454], p < 0.05), decreased serum Alb (HR:0.943, 95% CI [0.903–0.984], p < 0.05), Scr (HR: EXP(2.076–0.892*In(t)), p < 0.001), higher CKD stages (HR:6.984, 95% CI [4.185–11.656], p < 0.001), presence of proteinuria (HR:8.582, 95% CI [1.163–63.300], p < 0.05), prevalence of CVD (HR: EXP(2.813–0.894*In(t)), p < 0.001) were independent risk factors for KRT endpoint (Figure 2(B)). The gene discussed is ALB; the disease is diabetic kidney disease.