The significance of abnormal CD13/HLA-DR expression was retained in a multivariable Cox regression model when adjusting for age, whether patients had 2 or more comorbidities (including splenomegaly), and prior exposure to radiation therapy (HR, 2.97 [95% CI, 1.37-6.46]; P = .006) Table 4. The gene discussed is ANPEP; the disease is Splenomegaly.