In the network, it was predicted that matrine exerted anti-HCC effect has the characteristics of multilinks and multilevels possibly through acting on the vital targets (MMP7, ABCC1, PTGS1, HTR3B, HDAC10, etc.); thus, affecting 158 metabolism-related genes (FPGS, SIAE, GCLM, GCLC, HADHA, MPO, etc.), eventually affecting metabolic pathways. Here, HTR3B is linked to hepatocellular carcinoma.