Seo et al. (2019) showed that ALDH2 deficiency exacerbates alcohol-associated HCC development both in patients and mouse models. It has been reported that the expression of AGXT2 was downregulated in HCC and correlated with a poor prognosis for HCC patients (Cai et al., 2020). The gene discussed is AGXT2; the disease is hepatocellular carcinoma.