ALKBH1 and acute myeloid leukemia: These evidences are of particular interest for AML because many of these demethylase enzymes, which require ascorbate as a cofactor, are deregulated in the process of leukemogenesis (Das et al., 2021), including lysin-specific demethylases (Castelli et al., 2018), the Jumonji C (JmjC) domain containing histone demethylases (JHDMs) (Wang et al., 2011a; Staehle et al., 2021), the ALKB homolog (ALKBH) family of nucleic acid demethylases (Gerken et al., 2007; Yi et al., 2010) and TET enzymes (Castelli et al., 2018; Das et al., 2021).