GAPDH and colorectal cancer: As reported by Yun et al. (2015), in KRAS and BRAF-mutated colorectal cancer, this reduction triggers scavenging of glutathione (GSH), induces oxidative stress, inactivates glyceraldehyde 3-phosphate dehydrogenase (GAPDH), inhibits glycolytic flux and leads to an energy crisis with subsequent cell death (van der Reest and Gottlieb, 2016).