IL-8 is a vital inflammatory response factor that regulates tumor behavior, reduces LNCaP cell (an AR-dependent prostate cancer cell line) sensitivity to ADT, downregulates prostate-specific antigen (PSA) and AR, and activates the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. The gene discussed is KLK3; the disease is prostate cancer.