Four differentially expressed genes related to glycometabolism were more closely related to the OS of patients with HCC: glucose-6-phosphate dehydrogenase (G6PD), centromere protein A (CENPA), stanniocalcin 2 (STC2), and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). The gene discussed is CENPA; the disease is hepatocellular carcinoma.