Although CAST, CCDC6 and ERLIN1 are gene signatures of the high mitophagy subtype (cluster C), Kaplan-Meier analysis suggests that CAST and CCDC6 are risk factors for the prognosis of patients with PAAD, while ERLIN1 does not affect the prognosis (Supplementary Figure S4). Here, CAST is linked to pancreatic adenocarcinoma.