CCDC6 and pancreatic adenocarcinoma: Although CAST, CCDC6 and ERLIN1 are gene signatures of the high mitophagy subtype (cluster C), Kaplan-Meier analysis suggests that CAST and CCDC6 are risk factors for the prognosis of patients with PAAD, while ERLIN1 does not affect the prognosis (Supplementary Figure S4).