Hyperactivated mTOR signaling, including phosphorylated- S6K-1, 4E-BP1 and AKT, are observed in lesional skin of psoriasis patients, supporting a pathological function of mTOR in psoriasis (Madonna et al., 2012; Buerger et al., 2013; Buerger et al., 2017; Buerger, 2018) (Table 1). This evidence concerns the gene AKT1 and psoriasis.